Opportunity Information: Apply for PAS 22 207
The HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K23 - Clinical Trial Required) is an NIH-funded career development grant designed to help early career researchers and early career clinicians who already have a foundational background in addiction build real expertise in implementation science. The focus is not simply on testing whether an addiction-related intervention works under ideal conditions, but on learning how to put evidence-based practices into routine use across real-world clinical and community settings, where barriers like staffing, workflow, patient access, financing, stigma, and local policy often determine whether care actually improves. The award is structured around two integrated pieces: a mentored training plan in implementation science methods and a companion research project that applies those methods to a concrete implementation challenge in substance use prevention or treatment.
A central expectation is that the proposed research and training align with one or more priority domains from the HHS Overdose Prevention Strategy. Applicants are asked to focus their implementation science project in at least one of four areas: primary prevention (including appropriate opioid prescribing), opioid use disorder (OUD) treatment, harm reduction, and/or recovery support services. In practice, that could mean studying strategies to improve uptake of evidence-based prescribing and pain management practices, increasing access to medications for OUD, expanding adoption of harm reduction services, or strengthening recovery supports so that people can sustain treatment gains. The throughline is that projects should be about implementation: understanding and overcoming the practical, system-level, and behavioral hurdles that keep proven approaches from being delivered consistently and equitably.
The broader goal of the opportunity is workforce-building. NIH is using this FOA to grow a pipeline of investigators who can respond to the overdose crisis with rigorous implementation research, improve the quality of addiction care over the long term, and eventually become the next generation of implementation science leaders, collaborators, and mentors. That emphasis on career development means reviewers will look for a strong mentorship team, a credible plan for gaining implementation science competencies, and a project that is both methodologically sound and positioned to produce a trajectory of future research funding and impact.
This is a K23 mechanism and it is explicitly "Clinical Trial Required," meaning the application is expected to include a clinical trial component as defined by NIH, rather than being purely observational or secondary analysis. The research portion should be designed so that it can generate interpretable evidence about implementation strategies, outcomes, and contextual factors. While the exact approach can vary widely, the intent is that the applicant will use established implementation science frameworks and measures to evaluate how best to integrate and sustain evidence-based prevention or treatment practices in routine care environments.
Eligibility is broad and includes many organization types that can serve as the applicant institution. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other categories. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized ones, and U.S. territories or possessions.
There are also clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as the applicant institution. At the same time, foreign components are allowed when they meet the NIH Grants Policy Statement definition, which typically means a U.S.-based applicant can include certain foreign elements in the project if they are justified and compliant with NIH policy.
Administrative details from the listing include the Funding Opportunity Number PAS-22-207, the sponsoring agency as the National Institutes of Health, the funding instrument type as a grant, and the activity category spanning education and health (consistent with a mentored career development award). The original closing date shown is 2025-11-12. An award ceiling and expected number of awards are not specified in the provided information, which usually means applicants should rely on the full FOA and NIH institute-specific guidance for budget and award expectations.Apply for PAS 22 207
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K23 - Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.242, 93.273, 93.279, 93.398.
- This funding opportunity was created on 2022-07-14.
- Applicants must submit their applications by 2025-11-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K23 - Clinical Trial Required)?
This opportunity is an NIH-funded mentored career development award (K23) designed to help early career researchers and early career clinicians with a foundational background in addiction develop strong, practical expertise in implementation science. The award combines mentored training with a research project focused on implementing evidence-based substance use prevention or treatment practices in real-world settings.
What is the main goal of this funding opportunity?
The broader goal is workforce-building: NIH aims to grow a pipeline of investigators who can address the overdose crisis through rigorous implementation research, improve addiction care over the long term, and develop into future leaders, collaborators, and mentors in implementation science.
What does "implementation science" mean in the context of this award?
Implementation science here is about learning how to put evidence-based prevention and treatment practices into routine use across real-world clinical and community settings. The focus is not just whether an intervention works under ideal conditions, but how to overcome practical barriers that affect uptake and sustainability, such as staffing, workflow, patient access, financing, stigma, and local policy.
What are the required components of the K23 award structure?
The award is structured around two integrated components: (1) a mentored training plan in implementation science methods and (2) a companion research project that applies implementation science methods to a specific implementation challenge in substance use prevention or treatment.
Does the proposed project need to align with any federal priority areas?
Yes. A central expectation is alignment with one or more priority domains from the HHS Overdose Prevention Strategy. Applicants are asked to focus their implementation science project in at least one of four priority areas.
What are the four priority areas applicants are asked to focus on?
Applicants are asked to focus on at least one of the following areas: (1) primary prevention (including appropriate opioid prescribing), (2) opioid use disorder (OUD) treatment, (3) harm reduction, and/or (4) recovery support services.
What are examples of topics that could fit within the priority areas?
Examples described include studying strategies to improve uptake of evidence-based prescribing and pain management practices, increasing access to medications for OUD, expanding adoption of harm reduction services, and strengthening recovery supports so people can sustain treatment gains. Across these examples, the throughline is implementation: improving consistent and equitable delivery of proven approaches.
Is this opportunity primarily about developing new interventions?
Based on the description provided, the emphasis is on implementing evidence-based practices in routine care and community settings rather than only testing whether an intervention works under ideal conditions.
What does "Clinical Trial Required" mean for this FOA?
This K23 is explicitly designated "Clinical Trial Required," meaning the application is expected to include a clinical trial component as defined by NIH, rather than being purely observational or limited to secondary data analysis.
What should the research portion of the award be designed to produce?
The research portion should be designed to generate interpretable evidence about implementation strategies, outcomes, and contextual factors that affect integrating and sustaining evidence-based prevention or treatment practices in routine care environments.
Are there expectations about the methods used in the research project?
While the exact approach can vary, the intent is that applicants will use established implementation science frameworks and measures to evaluate how best to integrate and sustain evidence-based practices in real-world settings.
What will reviewers likely look for in a competitive application?
The description emphasizes career development, so reviewers are expected to look for a strong mentorship team, a credible plan to gain implementation science competencies, and a project that is methodologically sound and positioned to support a future trajectory of research funding and impact.
Who is the intended applicant (career stage/background)?
The award is intended for early career researchers and early career clinicians who already have a foundational background in addiction and want to build deeper expertise in implementation science.
Which organizations are eligible to apply as the applicant institution?
Eligibility is broad. Eligible applicant institutions include, among others: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other categories described in the listing.
Are any specific institution types highlighted as additional eligible applicants?
Yes. The FOA highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized ones, and U.S. territories or possessions.
Can non-U.S. (foreign) organizations apply as the applicant institution?
No. Non-domestic (non-U.S.) entities are not eligible to apply as the applicant institution for this opportunity.
Can a U.S.-based applicant include a foreign component in the project?
Yes, foreign components are allowed when they meet the NIH Grants Policy Statement definition. This typically means a U.S.-based applicant may include certain foreign elements if they are justified and comply with NIH policy.
Are non-domestic components of U.S. organizations eligible?
No. The provided information states that non-domestic components of U.S. organizations are not eligible to apply as the applicant institution. (Separately, foreign components may be allowed under NIH policy when properly justified.)
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number provided is PAS-22-207.
Which agency sponsors this funding opportunity?
The sponsoring agency listed is the National Institutes of Health (NIH).
What type of funding instrument is this?
The funding instrument type is a grant.
What is the activity category for this opportunity?
The activity category spans education and health, consistent with a mentored career development award focused on building implementation science expertise in substance use prevention and treatment.
What is the closing date shown for this opportunity?
The original closing date shown in the listing is 2025-11-12.
Is there an award ceiling or an expected number of awards provided?
No. The provided information does not specify an award ceiling or an expected number of awards. Applicants are expected to rely on the full FOA and NIH institute-specific guidance for budget and award expectations.
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| NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional) Apply for PAR 22 216 Funding Number: PAR 22 216 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required) Apply for PAS 22 206 Funding Number: PAS 22 206 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Galvanizing Health Equity Through Novel and Diverse Educational Resources (GENDER) Research Education R25 (R25 Clinical Trial Not Allowed) Apply for RFA OD 22 015 Funding Number: RFA OD 22 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Limited Competition: Cancer Immune Monitoring and Analysis Centers (CIMACs) and Cancer Immunologic Data Center (CIDC) (U24 Clinical Trial Not Allowed) Apply for RFA CA 22 038 Funding Number: RFA CA 22 038 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Early Detection Research Network: Clinical Validation Centers (U01 Clinical Trial Optional) Apply for RFA CA 22 039 Funding Number: RFA CA 22 039 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Early Detection Research Network: Biomarker Characterization Centers (U2C Clinical Trial Not Allowed) Apply for RFA CA 22 040 Funding Number: RFA CA 22 040 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Expanding Collaborative Implementation Science to Address Social and Structural Determinants of Health and Improve HIV Outcomes (R24 Clinical Trial Not Allowed) Apply for RFA MH 22 191 Funding Number: RFA MH 22 191 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Expanding Collaborative Implementation Science to Address Social and Structural Determinants of Health and Improve HIV Outcomes (R01 Clinical Trial Required) Apply for RFA MH 22 190 Funding Number: RFA MH 22 190 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Biology of Bladder Cancer (R01 Clinical Trial Optional) Apply for PAR 22 218 Funding Number: PAR 22 218 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Cellular and Molecular Mechanisms of Prion-Like Aggregate Seeding, Propagation, and Neurotoxicity in AD/ADRD (R01 Clinical Trial Not Allowed) Apply for PAR 23 023 Funding Number: PAR 23 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Research Studies to Develop and Implement Interventions to Prevent Opioid Misuse in Community Health Centers (R61/R33 Clinical Trial Required) Apply for RFA DA 23 048 Funding Number: RFA DA 23 048 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Biology of Bladder Cancer (R21 Clinical Trial Optional) Apply for PAR 22 219 Funding Number: PAR 22 219 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| NCI Outstanding Investigator Award (R35 Clinical Trial Optional) Apply for RFA CA 22 045 Funding Number: RFA CA 22 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| HEAL Initiative: Therapeutics Development for Opioid Use Disorder in Patients with Co-occurring Mental Disorders (UG3/UH3 - Clinical Trial Optional) Apply for RFA DA 23 049 Funding Number: RFA DA 23 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Global Implementation Science for Equitable Cancer Control (GlobalISE Cancer Control, U54 Clinical Trial Optional) Apply for RFA CA 22 019 Funding Number: RFA CA 22 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R01 Clinical Trial Not Allowed) Apply for RFA DE 23 015 Funding Number: RFA DE 23 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R21 Clinical Trial Not Allowed) Apply for RFA DE 23 016 Funding Number: RFA DE 23 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| NIDA REI: Addressing Racial Equity in Substance Use and Addiction Outcomes Through Community-Engaged Research at Minority Serving Institutions (R01 Clinical Trial Optional) Apply for RFA DA 23 032 Funding Number: RFA DA 23 032 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA REI: Addressing Racial Equity in Substance Use and Addiction Outcomes Through Community-Engaged Research (R01 Clinical Trial Optional) Apply for RFA DA 23 013 Funding Number: RFA DA 23 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA REI: Research on Neurocognitive Mechanisms Underlying the Impact of Structural Racism on the Substance Use Trajectory (R61/R33 Clinical Trial Optional) Apply for RFA DA 23 028 Funding Number: RFA DA 23 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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